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The ·¬ÇÑÊÓƵ/American Stroke Association previously offered the opportunity to be included in clinical research studies. This initiative allowed participants to contribute to
groundbreaking research that aimed to improve cardiovascular and stroke care. By being part of these studies, individuals helped advance scientific knowledge and potentially benefited from new treatments and therapies. All Get With The Guidelines® (GWTG) research can be found in our AHA GWTG Online Library.

ARAMIS: Addressing Real-world Anticoagulant Management Issues in Stroke

Clinical practice for the management of non-valvular atrial fibrillation (AF) was rapidly changing and new oral anticoagulants were approved by the FDA. The ARAMIS registry was designed to provide important and timely insight into the management of acute stroke patients who were on novel oral anticoagulants in community practice, the AHA worked in partnership with Duke Clinical Research Institute (DCRI) to promote this registry. Building upon the existing infrastructure of the nation’s largest ongoing stroke registry, ·¬ÇÑÊÓƵ’s Get With The Guidelines, the ARAMIS registry was a multicenter, prospective, observational study of AIS and ICH patients on home anticoagulation therapy. The ARAMIS registry was fully observational, and there were no treatment or management strategies directed by the study protocol. All treatment decisions were at the discretion of treating physicians.

PCORI (Patient-Centered Outcomes Research Institute) Heart Failure Study

With support from a PCORI research grant, Vanderbilt University Medical Center and the ·¬ÇÑÊÓƵ teamed up to study heart failure care in the Emergency Department. Nearly one
million ED visits for AHF occurred annually in the United States, and over 80% resulted in a hospital admission. Most importantly, vulnerable patients were discharged from the ED more often than
non-vulnerable patients and experienced a disproportionate increase in subsequent ED visits and hospital admissions. Get With The Guidelines®- Heart Failure (GWTG-HF) is currently successful in
the inpatient setting and improves processes of care and mitigates disparities in HF outcomes. However, patients discharged from the ED did not receive this benefit. The GWTG Interventions to Reduce Disparities in AHF Patients Discharged from the ED (GUIDED HF) had the potential to significantly impact clinical and patient-centric outcomes. GUIDED HF implementation strategy
could determine whether this approach was effective at improving outcomes and reducing disparities.

PROSPER: Patient-centered Research into Outcomes Stroke Patients prefer and Effectiveness Research

Every 40 seconds, someone in the U.S. had a stroke, with almost ¼ of these being recurrent strokes. The prognosis after the stroke remained poor, with a 1-year mortality rate of 15-30%. Many
questions remained unanswered for real-world stroke survivors regarding which therapies would have the greatest impact on their well-being. PROSPER was a national, sustainable model designed
to improve decision-making and patient-centered stroke outcomes through comparative effectiveness research. Using Get With The Guidelines®- Stroke data linked with Medicare claims, we evaluated outcomes prioritized by stroke survivor focus groups and surveys in three therapeutic areas with the focus on primary outcome of being independent and without significant health problems.

MaRISS: Mild and Rapidly Improving Stroke Symptoms

AHA teamed up with the University of Miami for an important three-year research study to evaluate treatment options for patients with mild and rapidly improving stroke symptoms by analyzing data from 100 hospitals participating in the Get With The Guidelines®- Stroke quality program.